医薬品工業

製剤装置粒子流れの数値シミュレーション
六車嘉貢
【要素的】 特集 11巻1号(1997)  製剤; 粒子;
Numerical simulation of the particulate flows has become possible by using discrete element method (DEM) with high performance computers. Calculations of particle motion in three kinds of pharmaceutical apparatus done by the author are reviewed. A centrifugal tumbling granulater, a rotating vessel type mixer and a screw feeder are dealt with. The present simulations predict well the realistic particulate flows. Pharmaceutical industries manufacture products which affect human life. Therefore it is necessary to make the process validation which guarantees the security of life and the effect of a medicine. It is important to know the behavior of particles in detail in order to control the quality 01 pharmaceuticals. The numerical simulation makes it possible to know the detailed information such as the three dimensional particle behavior, the interaction between particles and the effect of condition of equipment. These information is helpful in deepening out understanding powder processes.
医薬品のコーティング技術と流動層
福森義信・市川秀喜
【要素的】 特集 18巻3号(2004)  医薬品; コーティング; 流動層;
この記事はまだJ-Stage上に登録されていません。未登録記事は順次登録していく予定です。
医薬品製造における混相流の数値解析
六車嘉貢
【要素的】 特集 18巻3号(2004)  医薬品; 数値計算;
この記事はまだJ-Stage上に登録されていません。未登録記事は順次登録していく予定です。
経口固形製剤の製造工程における混相流のかかわりとPAT
谷野忠嗣
【巨視的】 特集 19巻3号(2005)  PAT;
この記事はまだJ-Stage上に登録されていません。未登録記事は順次登録していく予定です。
固液2相流系における造粒機構と顆粒剤製造-医薬品製造工程における結晶多形転移現象の解析-
大塚誠
【巨視的】 特集 19巻3号(2005)  固液; 医薬品; 造粒;
この記事はまだJ-Stage上に登録されていません。未登録記事は順次登録していく予定です。
制癌剤を内包したポリ乳酸マイクロカプセルの表面形態制御
西野悟・北村吉朗・吉澤秀和
【要素的】 特集 19巻3号(2005)  マイクロカプセル; 表面; 医薬品;
この記事はまだJ-Stage上に登録されていません。未登録記事は順次登録していく予定です。
医薬品造粒物の物性評価技術とProcess Analytical Technology(PAT)のキーパラメータ
米持悦生
【要素的】 特集 19巻4号(2005)  PAT; 造粒; 医薬品;
この記事はまだJ-Stage上に登録されていません。未登録記事は順次登録していく予定です。
噴霧乾燥式流動層造粒法による医薬品粉末注射剤の製造
辻本広行・原香織・山本正治・竹島和男
【要素的】 特集 19巻4号(2005)  噴霧; 造粒; 医薬品;
この記事はまだJ-Stage上に登録されていません。未登録記事は順次登録していく予定です。
ドラッグデリバリーシステム
有馬英俊
【要素的】 特集 19巻4号(2005)  ドラッグデリバリ; 医薬品;
この記事はまだJ-Stage上に登録されていません。未登録記事は順次登録していく予定です。
超臨界二酸化炭素を利用したドラッグデリバリーシステムの製作
下山祐介
【要素的】 特集 27巻3号(2013)  超臨界; CO2; ドラッグデリバリ;
Supercritical carbon dioxide is expected as a solvent in nano-scale material preparations, such as rapid expansion of supercritical solutions (RESS), supercritical anti-solvent (SAS) precipitation, and supercritical solvent impregnation (SSI) due to the unique properties of carbon dioxide, non toxic, inflammable, and mild critical temperature and pressure 304.2 K and 7.3 MPa, respectively. In this work, the ophthalmic drug delivery systems were prepared by SSI method using carbon dioxide. The effects of water in SSI process on the drug release profile from the prepared drug delivery system were investigated. The knowledge of the solid-liquid-gas equilibria is very important for the process design in SSI process. The prediction model of the solid-liquid-gas in supercritical carbon dioxide mixture are also developed by using the equation of state combined with the molecular information, molecular surface charge density, surface area, and volume obtained from the quantum calculations.
注射剤における異物管理
山根賢治
【要素的】 特集 29巻1号(2015)  医薬品; バイオ; 生体;
To control safe administration of injection product, we should carefully handle foreign matters. Hospital sometimes encountered cases where insoluble matter formed during the preparation of injections. In order to deal with this situation, we discussed the mechanism of formation of the insoluble matter and countermeasures on manufacturing process. Insoluble matter was a critical problem for quality of drug product of injections. In this report, the review for general approach for the foreign matters on injection product was reported.
食品・医薬品に関する混相流のための数値シミュレーション
今井宏樹・三谷亮介・三野泰志・酒井幹夫
【巨視的】 特集 39巻2号(2025)  DEM-VOF; DEM-LBM; 自由度削減モデル;
In this paper, we present numerical studies on multiphase flows related to food and pharmaceutical applications, focusing on the Discrete Element Method (DEM) and solid–fluid interaction simulations using the DEM. Specifically, we describe numerical models of the DEM coupled with the Volume-of-Fluid method and the DEM coupled with the Lattice Boltzmann Method, along with their application examples. In addition, we present the studies regarding the Reduced-Order Model based on Proper Orthogonal Decomposition.
凍結乾燥プロセスにおける流れの問題
中川究也
【巨視的】 特集 39巻2号(2025)  凍結乾燥; 食品工学; 水蒸気;
Vacuum freeze-drying is known as one of the most effective drying methods for maintaining quality among the many drying techniques. The main feature of freeze-drying is that it uses the sublimation of ice as the primary principle of dehydration. In this paper, the author will consider how freeze-drying process can be linked from a device perspective and a product quality perspective in terms of “fluid flow”. The drying rate is determined by the balance between the sublimation rate, water vapor transfer within the material, the water vapor velocity in the dryer, and the frosting velocity on the cold trap. When the water vapor velocity within the device reaches Mach 1, it enters a choked flow state. Therefore, the conductance of the device and the performance of the cold trap are critical factors determining the drying performance. During the freeze-drying process, when the product temperature remains above the glass transition temperature of the freeze-concentrated phase, the collapse of product occurs. The degree of collapse is one of the major factors affecting product quality (product shrinkage, rehydration ability, inactivation of active substances, etc.), but establishing a quantitative evaluation method for this remains a significant challenge. This study presents the results of an analysis using CFD simulation to investigate how fluid flow during the drying process determines the degree of collapse.